HOMCOS 1.0 : HOmology Modeling of protein COmplex Structure
A Server to Predict Binding Sites and Protein Pairs of Protein-Protein Interaction
by Homology Modeling of Complex Structures
The new server HOMCOS is now available.
||:Modeling a heterodimeric 3D structure from two query sequences
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||:Modeling a homodimeric 3D structure from one query sequence
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:Identifying putative interacting proteins in Uniprot database for one query sequence.
- Fukuhara N., Kawabata T. "HOMCOS: A server to predict interacting protein pairs and interacting sites by homology modeling of complex structures". Nucleic Acids Research, Web server issue (2008),
36(Web Server issue):W185-W189.
- Fukuhara N., Go N. and Kawabata T.
"Prediction of Interacting Proteins from Homology-modeled Complex Structure Using Sequence and Structure Scores"
BIOPHYSICS, Vol.3 (2007), pp 13.
Notes for use
Homology to a known 3D structure of a protein complex
is a powerful tool to predict new interaction and interaction sites.
However, please note following two points:
- Interaction specificities among many homologous protein pairs
are generally difficult to predict.
- A pair of protein dimer 3D structures with
less than 30-40 sequence identity sometimes show
a diffrent structural topology. If a generated 3D model
is based on a remote homologous template strucutre, please be
careful to use it.
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Last modified : June 5, 2012
Lab for Structural and Functional Bioinformatics(NAIST)
Laboratory of Protein Informatics (Osaka University)